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MLB Opening Day 2025: Pitching Matchups & Start Times
Credit: Kamil Krzaczynski-USA TODAY Sports

Opening Day – Thursday

Milwaukee Brewers @ New York Yankees (3:00 EST, ESPN)

Freddy Peralta vs. Carlos Rodon

Baltimore Orioles @ Toronto Blue Jays (3:07 EST)

Zach Eflin vs. Jose Berrios

Philadelphia Phillies @ Washington Nationals (4:05 EST)

Zack Wheeler vs. MacKenzie Gore

Boston Red Sox @ Texas Rangers (4:05 EST)

Garrett Crochet vs. Nathan Eovaldi

The most intriguing early game on Opening Day pits two popular picks to represent the American League in the World Series. The host Texas Rangers won the AL Pennant in 2023 but finished below .500 last season as they dealt with numerous injuries and inconsistent play. Boston finished 2024 with an 81-81 record and improved in the offseason by adding former Astro Alex Bregman and Opening Day starter Garrett Crochet. Crochet faces an immediate test against a Texas lineup that will want to make a strong impression following last year’s letdown.

Pittsburgh Pirates @ Miami Marlins (4:10 EST)

Paul Skenes vs. Sandy Alcantara

San Francisco Giants @ Cincinnati Reds (4:10 EST)

Logan Webb vs. Hunter Greene

Los Angeles Angels @ Chicago White Sox (4:10 EST)

Yusei Kikuchi vs. Sean Burke

Cleveland Guardians @ Kansas City Royals (4:10 EST)

Tanner Bibee vs. Cole Ragans

New York Mets @ Houston Astros (4:10 EST)

Clay Holmes vs. Framber Valdez

Juan Soto taking the field as a New York Met for the first time is the headline in this matchup. However, this game is interesting for several reasons. The Mets will hand the ball to Clay Holmes — also a former Yankee — who will be making his first start since 2018. Across the diamond, Houston will look rather different. Club legend Alex Bregman is now with the Red Sox and star outfielder Kyle Tucker is in Chicago. Additionally, Jose Altuve is no longer at second base. Following a noticeable decline in the infield, Houston moved the former MVP to left field in the offseason.

Atlanta Braves @ San Diego Padres (4:10 EST)

Chris Sale vs. Michael King

Minnesota Twins @ St. Louis Cardinals (4:15 EST)

Pablo Lopez vs. Sonny Gray

Detroit Tigers @ Los Angeles Dodgers (7:00 EST, ESPN)

Tarik Skubal vs. Blake Snell

The defending champion Los Angeles Dodgers will host the Detroit Tigers in front of a national audience on Opening Day. One of last year’s best stories, the Tigers are looking to build upon their first trip to the postseason since 2014. Led by Cy Young winner Tarik Skubal, Detroit upset the Houston Astros in the ALWC before falling to the rival Cleveland Guardians. Now, Skubal will start the year in a pitcher’s duel with first-year Dodger Blake Snell. A two-time Cy Young winner, Snell will look to push the Dodgers to 3-0 on the season.

Chicago Cubs @ Arizona Diamondbacks (10:10 EST)

Justin Steele vs. Zac Gallen

Athletics @ Seattle Mariners (10:10 EST)

Luis Severino vs. Logan Gilbert

Friday

Colorado Rockies @ Tampa Bay Rays (4:10 EST)

Kyle Freeland vs. Ryan Pepiot

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